Cosmetic preparation containing 2-phenyl-benzoxazoles

ABSTRACT

The invention relates to ultraviolet absorbers with a specific absorption range which makes them suitable for cosmetic uses. These ultraviolet absorbers correspond to the formula WHERE R1 represents a hydrogen atom or an alkyl radical, one of the symbols A1 or Z1 is a sulphonic acid function and Z1, when A1 stands for one of the above-mentioned sulphonic acid functions, represents a hydrogen atom or an alkyl group, or conversely A1 represents a hydrogen atom when Z1 stands for one of these sulphonic acid functions.

United States Patent Guglielmetti et al.

[ COSMETIC PREPARATION CONTAINING Z-PHENYL- BENZOXAZOLES [72] Inventors: Leonardo Guglielmetti, Birsfelden; Max Duennenberger, Frenkendorf, both of Switzerland [63] Continuation-impart of Ser. No. 630,183, April 12, 1967, abandoned.

[30] Foreign Application Priority Data April 21, 1966 Switzerland ..581 H66 [52] US. Cl. ..424/59, 260/307.4, 424/47, 424/272, 424/285, 424/308, 424/324 [51] Int. Cl. ..A6ll 23/00 [58] Field of Search ..424/59, 272; 260/307.4

[56] References Cited UNITED STATES PATENTS 2,334,348 11/1943 Miglarese ..260/307.4 X 2,104,492 l/ 1938 Merkel et a1. ..424/59 3,095,422 6/ 1963 Duennenberger et [73) Assignee: Ciba-Geigy AG, Basel, Switzerland 51 Oct. 3, 1972 FOREIGN PATENTS OR APPLICATIONS 936,120 9/1963 Great Britain ..260/307.4

Primary ExaminerAlbert T. Meyers Assistant Examiner-Dale R. Ore

Attorney-I-Iarry Goldsmith, Joseph G. Kolodny and Mario A. Monaco [57] ABSTRACT The invention relates to ultraviolet absorbers with a specific absorption range which makes them suitable for cosmetic uses. These ultraviolet absorbers correspond to the formula where R, represents a hydrogen atom or an alkyl radical, one of the symbols A, or Z, is a sulphonic acid function and Z,, when A, stands for one of the abovementioned sulphonic acid functions, represents a hydrogen atom or an alkyl group, or conversely A, represents a hydrogen atom when Z, stands for one of these sulphonic acid functions.

7 Claims, No Drawings COSMETIC PREPARATION CONTAINING 2- PHENYL-BENZOXAZOLES This is a continuation-in-part of our copendin'g patent application Ser. No. 630,183, filed Apr. 12, 1967, now abandoned.

The present invention provides specific derivatives of Z-phenylbenzoxazole and is especially concerned with their use as ultraviolet absorbers for cosmetic purposes.

Various ultraviolet absorbers for-cosmetic preparal0 (I) Z1 \c i o/ Q where R, represents a hydrogen atom or an alkyl radical containing one to six carbon atoms,

one of the symbols A, or Z, is a sulphonic acid function of the series --SO ,H or -SO,,Me or SO NHX, (where Me is an alkali metal ion, ammonium ion or amine salt ion) and X, represents a hydrogen atom, an alkyl group containing one to 12 carbon atoms or a hydroxyalltyl group containing to four carbon atoms, and 2,, when A, stands for one of the above-mentioned sulphonic acid functions, represents a hydrogen atom or an alkyl group containing one to four carbon atoms, or conversely A, represents a hydrogen atom when Z, stands for one of these sulphonic acid functions. Among the compounds of the above Formula (I) those are of special value whose total molecule contains at least one alkyl group with one to four carbon atoms.

of special value within the scope of the present invention are the new Z-phenylbenzoxazole derivatives of th mu in which R represents a methyl group or a tertiary butyl group and A a group SO;,Me (where Me is an alkali metal ion or ammonium ion) or a group SO NHX (where X, stands for an alkyl group containing one to eight carbon atoms).

As examples of 2-phenyl-benzoxazole derivatives suitable for use according to this invention there may be mentioned the compounds shown in the following table, in which column I formula number, column [I 30 formula, column ii] melting point in C, uncorrected and column IV reference to the manufacturingprocess as described in greater detail below.

(CH;)iHN.HO=S

C CH, 0119mm; H038 (CHQ HN. H058 (CHshHN. Hons- Q Ha)2HN s NaOaS NaOsS I II III IV .t /N\ 162-163 E -Q- CH5NHO;S/ \O 11 1 t /N\ 185.5486 E l CH:NHO2S/ \O 12 v 1. /N\ I 244-245 E C -CH3 mN-ozs 0 1a Ho-oH,oH-NH-01s\ /N\ 161-162 F.

11 CH3(CH2)1-NH0;S\ /N\ 215-06 F.

C CH,

15 cHmc /N 213-215 A A considerable number of the afore-mentioned comz N pounds are new, above all. Compounds of the formula 0 R R W \t 16 N i c-Q-cwnm 1) A] 0 where A is the sulphonic acid function -SO H or SO Me or SO NHX, (Me being an alkali metal ion, ammonium ion or amine salt ion), and

X, represents a hydrogen atom, an alkyl group with one to 12 carbon atoms or a hydroxyalkyl group with one to four carbon atoms, as well as compounds of the formula and of a benzene-monocarboxylic acid chloride of the formula ln these formulas all symbols have the meanings defined above and 2 represents the sulphonic acid function.

Depending on the physical and chemical nature of the components the reaction may be performed in substance (for example in the melt) or in solution; in the latter case it is, of course, possible to use any solvent that has, on one hand, sufficient solvent power and, on the other hand, is chemically inert towards the reactants (example: dichlorobenzenes). The temperature range to be used for the reaction should be substantially adapted to the reactivity of the reactants; in actual manufacture the interval from to 250C will in general be used. It is advantageous to perform the reaction in the presence of a catalyst or assistant having a dehydrating action or favoring dehydration, for example, boric acid, paratoluenesulphonic acid, a phosphoric acid, sulphuric acid or the like. Advantageously, the amide primarily formed by heating the reactants (intermediate product) is converted into the corresponding benzoxazole compound by heating with a phosphorus halide.

According to another variant of the process for the manufacture of the compounds to be used according to this invention the starting material used is a 2-phenylbenzoxazole of the formula the formula whereas variant (b) gives rise to the compounds of the type (22) z.\ N\ R l [1 U oiois o For the above-mentioned variants (a) and (b) it is advantageous to maintain the reaction temperature within the range from 50 to 150C, preferably from 100 to 150C. The sulphonating agent is advantageously used in an excess over the theoretically required proportion and serves at the same time as solvent.

The 2-pheny1benzoxazole derivatives to be used according to this invention may be used as agents protecting the skin from ultraviolet rays. They can be made up in known manner into stable cosmetic preparations ready for immediate use. Advantageously, they are mixed or emulsified with, or preferably dissolved in, vehicle substances; such vehicles may be liquid or semisolid and include liquid organic diluents, for exam ple organic solvents such as alcohols or ketones, for example ethanol, isopropanol, glycerin, cyclohexanol, methylcyclohexanol; furthermore trichlorethylene, benzine, esters of vegetable or animal origin, such as vegetable or animal oils or fats, for example groundnut oil, cocoa butter or lanolin. Further suitable are mineral solvents such as liquid paraffin, white mineral oil, white petroleum jelly, or liquid petrolatum. If an aqueous dispersion of the ultraviolet absorber is desired, the latter can be directly finely dispersed in water with the aid of a suitable dispersant or it may be completely or partially dissolved in an organic vehicle (see above) and then dispersed or emulsified in water. It goes without saying that such mixtures and preparations may also contain further ingredients, for example skin care agents, insect repellants, deodorants, aromas or coloring matters. By a suitable choice of one or several vehicles and, if desired, further additives there are obtained solutions, ointments, pastes. creams, oils or emulsions.

With the use of suitable solvents, for example fiuorochloralkanes, it is also possible to manufacture spray preparations so-called aerosol sprays) which are kept in closed containers and on actuation of a valve are directly sprayed over the skin area to be protected.

The amount of new 2-phenylbenzoxazole to be incorporated with the cosmetic preparation may vary within rather wide limits depending on the type of the 4 preparation. For most practical purposes, however, a

quantity from 0.05 to 5, preferably from 1 to 3, percent by weight of 2-phenylbenzoxazole derivative, referred to the weight of the preparation as a whole, will be acceptable.

'" "The 2-pheny1benzoxazole derivatives to be used as ultraviolet absorbers according to this invention are particularly suitable as agents for protecting the skin because they are readily soluble in solvents conventionally used for cosmetic purposes. The phenylbenzoxazoles to be used according to this invention are especially advantageous because they absorb very strongly within the region from 290 to 320 my. and thus substantially absorb the ultraviolet rays up to. about 330m;.:. which cause reddening of the skin, but they do not affect rays of a higher wavelength above 340mg, whose tanning effect is desired as a rule. This behavior is not observed with other compounds having a similar constitution.

Unless otherwise indicated, parts and percentages in the following Manufacturing Instructions and examples are by weight.

MANUFACTURING lNSTRUCTlONS Av twenty five grams of the compound of the formula are dissolved at room temperature in 50 ml of chlorosulphonic acid, while being stirred heating to C and maintained for 1 hour at 100C. The reaction mixture is then cooled to room temperature and poured out over ice. The amorphous precipitate is suctioned off, taken up in ether and washed with a 2N- sodium carbonate solution and then with water until the washings run neutral. The ethereal solution is dehydrated with sodium sulphate and evaporated to dryness. Yield: 23.7 g of the compound of the formula 111 I3(:- SOz-Cl l l l SOg-Cl White needles from hexane, melting at 134 to 136C. Analysis: C l-l O NSC1; (307.76)

calculated: C 54.64; H 3.28; N 4.55; Cl 11.52; S

10.42% found: 54.41; 3.16; 4.51; 11.61; 10.58%.

White needles from hexane, melting at 99 to 100C. Analysis: C H O NsCl; (307.76)

Calculated: C 54.64; H 3.28; N 4.55%

found: 54.66; 3.43; 4.56%.

(c) 21) cm N SOr-Cl Needles from ligroin (boiling at 110 to 140C) melting at 134 to 135C. Analysis: C H O NsCl; (307.76)

calculated: C 54.64; H 3.28; N 4.55%

found: 54.14; 3.23; 4.50%.

White needles from ligroin (boiling at 110 to 140C) melting at 132 to 133C. Analysis: C 4H O NSCl; (307.76)

calculated: C 54.64; H 3.28; N 4.55%

found: 54.65; 3.20; 4.29%.

A solution of 132g of the compound of the formula (24) in 1 liter of hot dimethylformamide is refluxed for 3 hours. The reaction mixture is concentrated to about 150 ml and slowly mixed with 1 liter of alcohol, to yield 122 g of the compound of the formula (3) CH N 3 -Q- E soau-rm O CH:

in colorless crystals melting at 259 to 261C. After recrystallization from dimethylformamide-l-alcohol with the aid of active carbon it forms needles melting at 260 to 261C Analysis: C, H O N S; (376.48)

calculated: C 60.62; H 6.43; N 7.44; S 8.52%.

found: 60.57; 6.31; 7.45; 8.59%.

An analogous reaction of the compound of the Formula (25) gives rise to the compound of the formula CH: SOaH-HN OH: in the form of white needles from dimethylformamide-l-alcohol, melting at 229 to 230C. Analysis: C H O N S; (334.40)

calculated; C 57.47; H 5.43; N 8.38%. found: 57.42; 5.3 8.37% An analogous reaction of the compound of the formula 26) gives rise to the compound of the formula in small, white needles from ethanol+ether, melting at 179 to C. Analysis: C H O S; (334.40)

calculated: C 57.47; H 5.43; N 8.38; S 9.59%.

found: 57.56; 5.37; 8.15; 9.64%.

An analogous reaction of the compound of the formula (27) gives rise to the compound of the formula SOgH-HN in small, white needles from ethanol-l-ether, melting at 178 to 179C. Analysis: C, H, O N S; (334.40) zH O calculated: C 55.96; H 5.58; N 8.16; S 9.34%.

found: 55.94; 5.55; 8.22; 9.77%.

An analogous reaction of the compound of the Formula (28) gives rise to the compound of the formula in colorless crystals melting above 320C. After recrystallization from aqueous alcohol the melting point is still above 320C. Analysis: C,,H, O NSNa%H 0; (362.37)

calculated: C 56.34; H 4.73; N 3.86; S 8.85%.

found: 56.57; 4.73; 3.89; 8.87%.

In an analogous manner the compound of the Formula (4) furnishes the compound of the formula -so,-Na+

in small, white needles from aqueous alcohol, melting above 360C. Analysis: C H O NSNa; (31 1.29)

calculated: C 54.02; H 3.24; N 4.50; S 10.30%.

found: 54.34; 3.23; 4.62; 10.28%.

C. The compound of the Formula (9) may alternatively be prepared by direct sulphonation in the following manner:

One hundred-and-fifty grams of the compound of the formula HKCQ/ (j o are dissolved with stirring in 500 ml of sulphuric acid monohydrate. The reaction mixture is stirred on for 5 hours at 150C, then cooled to C and poured out over ice. While cooling, a sodium hydroxide solution of 30 percent strength is stirred in until the product of the Formula (9) precipitates in the form of the sodium salt. Yield: 170g (=72 percent of the theoretical). After three recrystallizations from water with the aid of active'carbon white needles are obtained which melt about 300C. 1 Analysis: C H NSO Na'H O (329.29) calculated: C 51.20; H. 3.68; N 4.27; S 9.80%

found: 50.84; 3.71; 4.20; 9.92%.

D. 154.6 grams of toluylchloride, 189.2 g of finely, powdered 2-aminopheno1-4-sulphonic acid and 2 ml of pyridine are suspended in 1 liter of orthodichlorobenzene. The reaction mixture is refluxed under nitrogen, during which hydrochloric gas is evolved. When hydrochloric gas is no longer being given off (after about 14 hours) the reaction mixture is cooled to C and the precipitate is suctioned off. Yield: 266g of the compound of the formula in the form of a white powder melting at 256 to 257C,

pentachloride and refluxed. When the evolution of hydrochloric gas has ceased (after about 17 hours), the hot reaction mixture is evaporated to dryness under vacuum, taken up in dioxane and slowly mixed with water until crystals settle out. Yield: 22 g of the compound of the formula HSCQ/ in the form of white crystals melting at 119 to 121C.

After recrystallization from hexane with the aid of active carbon the compound forms white needles melting at 124 to 125C. Analysis: C H O NSCl; (307.76)

calculated: C54.64; H 3.28; N 4.55; S 10.42; Cl

E. A mixture of 10 g of the compound of the Formula (25), 50 ml of ethanol and 20.8 ml of an ethylamine solution of 71.6 percent is refluxed for 2 hours. At room temperature, water is stirred into the reaction mixture until crystals settled out. Yield: 10g of the compound of the formula in the form of colorless needles melting at 162 to 163C. Analysis: C H N O S (316.37)

calculated: C 60.74; M 5.10, N 8.86; S 10.14% found: 60.60; 4.96; 8.69; 10.13%. In an analogous manner the compound of the Formula (25) and methylamine furnish the compound of the formula SOz-NHCHa 0 in the form of white needles from aqueous ethanol, melting at 185.5 to 186C. Analysis: C H O N S (302.34)

calculated: C 59.59; M 4.67; N 9.27%.

found: 59.85; 4.53; 9.22%.

An analogous reaction of the compound of the Formula (25) and ammonia gives rise to the compound of t rmula SOT-'NHZ H O C in the form of white needles from aqueous methanol, melting at 161 to 162C. Analysis: G l-1 N 05; (332.37)

calculated: C 57.82; H 4.85; S 9.65%

found: 58.07; 5.15; 9.52%.

An analogous reaction of the compound of the For-- mula (31) and octylamine furnishes the compound of th ormul H C C SOz-NH-(CHzh-CH:

are dissolved in 23 parts by volume of concentrated sulphuric acid at 70 C with stirring. The reaction mixture is cooled to C and 40 parts of oleum of 25 percent strengthare added dropwise in the course of 40 minutes at 0 to 15C. The reaction mixture is stirred at 18 to 18 C for another 3 hours and then poured into a solution of 40 parts of ammonium chloride in 130 parts of water, previously cooled to l0 C. The resulting suspension is stirred overmight at 40 to 50 C, filtered and washed with concentrated ammonium chloride solution until the filtrate shows neutral reaction. The residue is taken up in 40 parts of water, the suspension stirred for hald an hour, filtered with suction and dried in vacuo at 50 C. Approx. 15 parts of the ammonium salt of the formula are obtained which, after recrystallization from water in the presence of active carbon and Fullers earth,

form a white crystalline substance melting above 360 C.

F. Ten parts of the ammonium salt of Formula (32) an suspended in 100 parts of n-butanol, 10 parts of triethanolamine are added and the reaction mixture is refluxed under a nitrogen atmosphere until no further.

are obtained in the form of white crystals (meltingpoint: 145 to 146 C). After recrystallization from alcohol with addition of active carbon and Fullers earth the melting point does not change. In dimethyl formamide the compound of Formula (33) shows absorption maxima at 302, 309, and 324 nm and in water at 298 and 6 nrn.

EXAMPLE 1 (Cosmetic Formula) Cetiol (a mixture of esters of unsaturated fatty acids consisting predominantly of oleyloleate,

prepared from spermaceti) 10.00% stearin 6.00% water 89.95%. KOH 0.45% triethanolamine 1.10% compound of the formula (8) 2.50%

The sunburn cream formulated in this manner very strongly absorbs harmful rays that produce sunburn but readily passes tanning rays.

TABLE 2 Propyleneglycol water rectified alcohol 1 compound of the formula (9) The sunburn lotion prepared in this manner has an effect similar to that mentioned in Example 1.

EXAMPLE 3 Four parts of the compound of the Formula 10) are dissolved in 90 parts of ethanol and six parts of propyleneglycol, and 0.5 part of perfume oil is added. Forty parts of the solution thus obtained are charged into an aerosol container together with 60 parts of a mixture of equal proportions of trichloromonofluoromethane and dichlorofluoromethane. The aerosol spray thus obtained may be used as a sunburn preparation.

Instead of the compound (10) any one of the compounds of the formulas l l to 14) may be used with a corresponding result.

EXAMPLE 4 Ten parts of adipic acid-isopropyl-tetrahydrofurfuryl ester, five parts of benzoic acid diethylamide, eight parts of phthalic acid dimethyl ester and five parts of the compound of the Formula (10) or (11) are dissolved in 36 parts of groundnut oil and 36 parts of liquid paraffin, to form a sunburn preparation which repels insects.

EXAMPLE 5 Four parts of the compound of the Formula (1 1) or (14), 10 parts of glycerin monostearate, four parts of cetyl alcohol, one part of sodium cetylsulphate, one part of stearic acid and five parts of glycerin are intimately mixed and emulsified in 75 parts of water.

The resulting emulsion lends itself very well to being used as a non-fatty skin cream which protects the treated skin areas from sunburn.

EXAMPLE 6 With the triethanolamine salt of Formula (33) cosmetic preparations are made as follows 1. Cream A.

4 parts of paraffine oil 6 parts of a mixture of isopropyl myristate and stearate 4 parts of hexyl-laurate 2 parts of cetostearyl alcohol 3 parts of stearic acid 3 parts of sorbitanemonostearate polyglycolether 3 parts of sorbitane monostearate B.

2 parts of compound of formula (33) 5 parts of sorbitol solution of strength 0.25 parts of mixture of parahydroxybenzoic methyl and propylester 68 parts of water The triethanolamine salt is dissolved in the aqueous medium and the solution heated to 70 C. Composition A is heated to the same temperature, A and B are mixed and the mixture is cooled to room temperature. 2. Skin Milk A.

10 parts of a mixture of isopropyl myristate and palmitate 2 parts of hexadecylalcohol parts of hexyllaurate 1 part of cetostearylic alcohol 1 part of stearic acid 4 parts of sorbitane monostearate polyglycolether 3 parts of sorbitane monosteara'te B.

3 parts of compound of formula (33) 5 parts of sorbitol solution of 70 strength 0.25 part of mixture of of para-hydroxybenzoic from ultraviolet rays which contains as an ultraviolet ray absorber in a cosmetically acceptable carrier, from about 0.05 to 50 percent by weight of a Z-phenylbenzoxazole compound having the formula where R represents a member selected from the group consisting of hydrogen and alkyl of one to six carbons, one of A and Z is a member selected from the group consisting of SO H, SO Me 13 SO NHX,

Me being selected from the group consisting of an alkali metal ion, ammonium ion, a lower dialkyl amine salt ion, triethanolamine salt ion and ethanolamine salt ion, and X represents a member selected from the group consisting of hydrogen, alkyl of one to 12 carand bons and hydroxyalky] of one to four carbons, with the proviso that when A represents one of the aforesaid sulfonic groups, Z stands for a member selected from the group consisting of hydrogen and alkyl of one to four carbons, and that when 2 represents one of the afore-mentioned sulfonic groups. A stands for hydrogen.

2. A cosmetic preparation according to claim 1, wherein the Z-phenylbenzoxazole compound contains at least one alkyl of l to 4 carbons.

3. A cosmetic preparation according to claim 1, wherein the Z-phenylbenzoxazole compound has the formula N\ I g C R.

where R represents a member selected from the group consisting of methyl and tertiary butyl and A stands for from the group consisting of an alkali metal ion, an ammonium ion and a triethanolamine salt ion, and X represents alkyl of one to eight carbons.

4. A cosmetic preparation according to claim 1, wherein the Z-phenyloxazole compound is the triethanolamine salt of the 2-(4-methylphenyl)- benzoxazole-6-sulfonic acid of the formula 5. A process for protecting the skin from ultraviolet rays which comprises applying thereto the preparation defined in claim 1.

6. A process for protecting the skin from ultraviolet rays which comprises applying thereto the preparation defined in claim 3.

7. A process for protecting the skin from ultraviolet rays which comprises applying thereto the preparation defined in claim 4.

33 UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3,696,193 Dated October 3, 1972 Inuentofls) LEONARDO GUGLIELMETTI ET AL It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Column 13, line 29, delete "50" and substitute 5 the center portion of the formula should read line 2, before the last group delete "l3" and insert Signed and sealed this 25th day of June 19714;.

(SEAL) Attest:

EDWARD M.FLETCHER,JR. c. MARSHALL DANN Commissioner of Patents Attesting Officer 

2. A cosmetic preparation according to claim 1, wherein the 2-phenylbenzoxazole compound contains at least one alkyl of 1 to 4 carbons.
 3. A cosmetic preparation according to claim 1, wherein the 2-phenylbenzoxazole compound has the formula where R2 represents a member selected from the group consisting of methyl and tertiary butyl and A2 stands for -SO3 Me or -SO2NHX2, where Me is selected from the group consisting of an alkali metal ion, an ammonium ion and a triethanolamine salt ion, and X2 represents alkyl of one to eight carbons.
 4. A cosmetic preparation according to claim 1, wherein the 2-phenyloxazole compound is the triethanolamine salt of the 2-(4''-methylphenyl)-benzoxazole-6-sulfonic acid of the formula
 5. A process for protecting the skin from ultraviolet rays which comprises applying thereto the preparation defined in claim
 1. 6. A process for protecting the skin from ultraviolet rays which comprises applying thereto the preparation defined in claim
 3. 7. A process for protecting the skin from ultraviolet rays which comprises applying thereto the preparation defined in claim
 4. 